Excellent job Satinder for winning the top poster award at CRS meeting 2024

Al-Ahmady Lab received NC3Rs Network Primer Award to establish collaborations to share 3Rs technologies and approaches for ex-vivo myeloma model

Dr Al-Ahmady in collaboration with Dr Reinwald, Dr Pal (University of Bristol) and Dr AL-kaisi (University Hospital of Derby and Burton) received NC3Rs Network Primer Award to establish animal free ex-vivo myeloma model

Al-Ahmady Lab Summer Activity 2024

We had a great time at Monsal Head, Peak District. Very nice walk and outdoor picnic

Dr Al-Ahmady Received BBSRC Mid Range Equipment Grant to establish East Midlands Light Sheet Fluorescence Microscopy Facility

Soapbox Women 2024 _ Speaker’s Corner 13th of July 11-2 pm

Dr Al-Ahmady is part of the organising team of Nottingham Women in Science that will take place at the Speaker's Corner 13th of July 2024

Call for Volunteers is still open (scan QR code to apply)

Al-AhmadyLab at SHiMR Away Day July 2024

Dr Al-Ahmady Presented the Neurophysiology Theme at SHiMR away day.

Well done Jessica, Satinder and Asif for presenting your work at SHiMR Away Day.

Many Congratulations for Jessica on getting 1st Poster Prize. Very well deserved.

SHiMR Theme Imaging Research Meeting

Dr Al-Ahmady organised the second Imaging Theme Research Showcase in June 2021.

Jessica Presented her work on immuno-MRI at NTU.

Asif presented his day using micro-CT to image lytic lesions in a preclinical myeloma model.

UG research Showcase April 2024

Congratulations to our UG project students Megan (left) who received the Head of Department Prize, and Lilly (right) who received the Industrial Prize. Your achievements have made us all immensely Proud.

Focus on Challenges in Clinical Translation of Nanomedicine

Dr Zahraa Al-Ahmady accepted an invitation to serve as Guest Editor with Dr Acelya Yilmazer-Aktuna for a Special Issue of the journal Nano Futures - IOPscience (ISSN: 2399-1984). Invitations are now open to contributions for a short review, an opinion article or a perspective article on this special issue titled: Focus on Challenges in Clinical Translation of Nanomedicine

For more details about the Special Issue, please see IOPscience - Focus on challenges in clinical translation of nanomedicine. The target deadline for submissions is 31 August 2024.

Dr Zahraa Al-Ahmady is invited to give a talk at the Brain Conference, on March 15th, 2024, in London to cover their recent work on selective drug delivery for stroke.

For registration and abstract submission please visit: https://conference.guarantorsofbrain.org/poster/

Al-AhmadyLab at Neuroscience @ Nottingham Day, January 2024

Dr Al-Ahmady was invited to give a talk at the Neuroscience @ Nottingham Day, in January 2024.

Jessica Bates also presented a poster on her PhD work and was part of the organizing committee.

Al-AhmadyLab Submitted a Patent Application on a New Approach to Prevent Infections After Stroke

Here we describe a new treatment that offers better prevention of infections after stroke, by preventing the death of the B cells after stroke Lipid Nanoparticles | Powered by Inpart (in-part.com)

Nottingham Annual Stroke Meeting

Al-AhmadyLab Hosted the Nottingham Annual Stroke Meeting on the 1st of December 2023. This meeting is to allow ECR to present and discuss their work in the area of preclinical stroke at an early stage and encourages networking and collaboration with other academic groups based at Nottingham Trent University and the University of Nottingham.

Congratulations Dr Kaur !!

Satinderdeep Kaur successfully defended her Ph.D. thesis titled “Nanomedicine Based Approaches to Prevent Post-Stroke Infections” supervised by Dr. Zahraa Al-Ahmady, Dr Carl Nelson, and Prof Stuart Allan. Many Congratulations Dr Kaur.

Al-AhmadyLab at Stroke Immunology Meeting, Munich, September 2023

Satinderdeep Kaur and Jessica Bates presented their work at the 3rd Stroke Immunology Meeting in Munich, in September 2023. A great forum for neuroimmunology research.

Dr Zahraa Al-Ahmady was invited to give a keynote talk on ‘Using nanotechnology to deliver drugs across the BBB in stroke’ at the NIHR Stroke Workshop in London, September 2023.

NIHR Stroke Workshop 2023

Al-AhmadyLab at Preclinical Stroke Meeting, September 2023

Jessica Bates and Satinderdeep Kaur received travel awards to present their work at Preclinical Stroke Symposium titled “Expanding Stroke-Related Nanoparticle Brain Infiltration to Physiological Ageing: Possibilities To Effectively Target Age-Related Neurovascular Unit Changes” and “Lipid Vesicles Offer a Selective Splenic Targeting Strategy for Peripheral Immunomodulation Following Ischemic Stroke”, respectively. The meeting took place at the University of Edinburgh from the 4th-5th of September.

Our Lab is enjoying a summer day at Carsington Water, Aug 2023

Jessica Presented at the British Microcirculation and Vascular Biology Society 2023

Jessica Bates received a Student Assistant Scheme Travel Bursary from the British Microcirculation and Vascular Biology Society in June 2023 (Edinburgh) where she gave a talk titled “Targeting the Aged Blood-Brain Barrier with Lipid Nanoparticles: The Potential to Exploit Brain Vasculature Permeability in the Ageing Neurovascular Unit”.

Congratulations to Asif Syed

Asiffudin Syed received an oral presentation award for his talk presented at the NTU School of Science & Technology Research Student Conference (STAR 2023), titled “Nanomedical Approaches Towards the Treatment of Blood Cancers”.

Al-Ahmady Lab at BBSRC DTP Spring Conference 2023

Dr Al-Ahmady gave a talk and chaired a session at the annual BBSRC DTP Spring Conference, Nottingham 2023. Mitchell Hudson also gave a short talk on the plan of his PhD studies.

Jessica gave a talk at the 12th UK and Ireland BBB symposium, Dublin 2022

Congratulations Jessica !!

Well done Jess for winning 1st Poster Presentation Prize @ NTU STAR Conference 2022 on your PhD work investigating BBB alterations in ageing

A huge congratulations to Satinder for winning the 1st poster prize at the 13th CLINAM Summit 2022

Brain and Brain PET Meeting, Glasgow, 2022

Dr Al-Ahmady presented their recent work on intracerebral haemorrhage at the Brain and Brain PET meeting that took place in Glasgow in 2022

VJHemONC interview with Dr Al-Ahmady, International Myeloma Society (IMS) 2022

IMS 2022 | Anti-BCMA lipid-based nanoparticle therapeutic strategy for patients with multiple myeloma

In this interview, Dr Al-ahmady discusses the feasibility and advantages of a novel anti-BCMA lipid-based nanoparticle therapeutic strategy designed to improve the tolerance and availability of BCMA-directed therapies for patients with multiple myeloma. This interview took place at the 19th International Myeloma Society Meeting (IMS) held in Los Angeles, CA

Dr Al-A-hmady Gave a keynote lecture at the annual BBSRC DTP conference, Nottingham 2022

In this lecture, Dr Al-Ahmady discussed different Targeted Approaches for Stroke Treatment they are currently developing for both ischemic and haemorrhagic stroke. 

In the News

Over a 100 press release on our work on intracerebral hemorrhage including Evening Standard, Irish Examiner, Belfast Telegraph, Glasgow Times, MSN, Yahoo News and many others.

Satinder presented at Stroke Immunology, Munich 2022

Satinder presented a poster on her PhD work at the 2nd Stroke Immunology meeting that took place in Munich, March 2022.

Blocking Blood-Induced Brain Damage After Intracerebral Haemorrhage

Dr Zahraa Al-Ahmady received a prestigious award from Brain Research UK (PI) titled “Novel Targeted Approach to Inhibit Ferroptosis in a Rodent Model of Intracerebral Haemorrhage” in collaboration with Prof S. Allan, Dr B. Dickie and Dr A. Parry-Jones at the University of Manchester and Prof Sergio Rutella and Graham Ball at NTU.

This project is a follow-up to a recent work by Dr Al-Ahmady’s team showing a novel approach to selectively target brain damage in haemorrhagic strokes using tiny parcels made of lipids called liposomes. In this project, the team plans to package these liposomes with iron chelators to inhibit ferroptosis. By this, the team aim to get more of the iron-chelating drugs to the brain without exposing the rest of the body to those drugs which have been shown to have dose-limited toxicities in patients. The team will be comparing the effect of the packaged iron chelator to those given without packaging on mice with brain haemorrhage to prove that this new technology is more efficient in reducing or preventing brain damage after haemorrhagic strokes.

More on this project can be found here.

SPECT/CT live images show the selective entry of lipid nanoparticles into the injured side of the brain (right) following haemorrhagic stroke compared to healthy mice.

Al-AhmadyLab hosted the 11th UK and Ireland BBB Virtual Symposium 2021

The 11th UK and Ireland BBB symposium was hosted by NTU this year and was organised by Dr Zahraa Al-Ahmady, Dr Richard Hulse, Jessica Bates, Satinderdeep Kaur and Lydia Hardowar. The symposium was sponsored by Nanostring.com and took place virtually on Friday 12th November 2021 with more than 90 participants. This symposium focuses on providing an opportunity for early-career researchers to present their investigations into blood-brain barrier function and how this is implicated in neurological disease development and progression. This year we had the pleasure to welcome international leading expert Professor Berislav V Zlokovic from Zilkha Neurogenetic Institute, University of Southern California).

Dr Al-Ahmady gave a talk titled "Lipid Nanoparticles Offer a Selective Splenic Targeting Strategy Following Acute Brain Injury" at the Stroke Immunology Metting, Munich, 2021.

Dr Al-Ahmady Presented at the 8th and 9th UK and Ireland BBB symposiums that took place in 2018 and 2019

Dr Al-Ahmady chaired Degenerative Diseases Nanomedicine Session at 11th European and Global Summit for Clinical Nanomedicine, Targeted Delivery and Precision Medicine

Dr Al-Ahmady gave oral talks at CLINAM 2018 and CLINAM 2020

In the News

The links below are from press releases related to our work in ACS Nano (2019), doi: 10.1021/acsnano.9b01808:

https://aboutmanchester.co.uk/tiny-transporters-could-deliver-treatment-to-stroke-patients/ 

https://phys.org/news/2019-11-tiny-treatment-patients.html

https://www.eurekalert.org/pub_releases/2019-11/uom-ttc110619.php

https://eandt.theiet.org/content/articles/2019/11/tiny-transporters-could-deliver-treatment-to-stroke-patients/

https://amp.flipboard.com/@ladydocs/tiny-transporters-could-deliver-treatment-to-stroke-patients/a-Aetu56L_Th2okXoBM8GH3A%3Aa%3A6126148-ce18bab6d0%2Fphys.org

https://www.parallelstate.com/news/tiny-transporters-could-deliver-treatment-to-stroke-patients/181114